Choose addresses that match the message purpose
Use a From address recipients recognize and can associate with the organization or service. Replies to a notification-only mailbox may go to a monitored support address through Reply-To, provided recipients know how to get help.
Check domain authentication and provider requirements when using different domains. Sender identity, signing, and policy alignment can affect acceptance, and receiving systems may display mismatched addresses differently.
Test the recipient experience
Send tests to several mail clients and confirm the displayed sender, reply destination, and controls behave as intended. Verify replies reach a monitored inbox and automated messages do not imply a person will answer if no one does.
Document each address's purpose and owner so future template edits do not redirect replies accidentally. Keep both fields truthful and consistent with sender policies.